The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Chemistry of the Elements (2nd Edn. (1999) ainsi que Gibbs et al. Furthermore, study data from human volunteers who were given perchlorate (at dosages up to 0.5 mg/kg/day for two weeks), and perchlorate-manufacturing workers, revealed no apparent change in various parameters of thyroid function despite exposure to the equivalent of anywhere from 200 to 17,500 ppb of perchlorate in water. 6,7 The clinical study, however, studied only short-term exposure … 1979 Jun;91(2):271-81. doi: 10.1530/acta.0.0910271. Perchlorate does not exist on its own; it must be bound to other chemicals, such as ammonia, magnesium, and potassium. Women with thyroid peroxidase antibodies might be less able to maintain normal thyroid function when exposed to perchlorate and thiocyanate. This single precipitation reaction exploits the low solubility of KClO 4, which is about 1/100 as much as the solubility of NaClO 4 (209.6 g/100 mL at 25 °C). The NOAEL for potassium perchlorate is 1.18 mg /kg bw/d. In pharmacological doses, perchlorate decreases the active transport of iodine into the thyroid. COVID-19 : Politique transitoire visant la vente et l'importation de produits nettoyants en provenance des États-Unis. Perchlorate is an inorganic anion that is a potent competitive inhibitor of the sodium-iodide symporter (NIS) found on the basolateral membrane of thyroid cells. Moyens d'extinctionInformations supplémentaires: Eau. Br Med J (13 May):1368–1369. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Perchlorate can form naturally in the air and is found at low levels in rain or snow. The reduction of the iodide pool by perchlorate has dual effects – reduction of excess hormone synthesis and hyperthyroidism, on the one hand, and reduction of thyroid inhibitor synthesis and hypothyroidism on the other. Authors P T Männistö, T Ranta, J Leppäluoto. Son ingestion cause une inhibition de l'utilisation de l'iode par la thyroïde et par conséquent de l'hypothyroïdie. Par analogie avec le perchlorate de sodium : Ce produit est irritant pour les yeux. High doses of potassium iodide are effective to block radioiodine thyroid uptake and to prevent development of thyroid cancer years later. Votre session po​urrait être interrompue ou non enregistrée durant cette période. Overview; Fingerprint; Abstract. It's been found in milk, fruit, and vegetables, as well. Toutes les études effectuées avec des composés de perchlorate ont été considérées puisque c'est l'ion perchlorate qui est responsable des effets toxiques (ATSDR, 2008). Potassium perchlorate has been used therapeutically to treat hyperthyroidism resulting from an autoimmune condition known as Graves' disease. 25 conducted a randomized trial in which 13 men and women consumed a placebo, 0.5, or 3 mg/day of potassium perchlorate for 6 months. [15], However, when the average perchlorate absorption in perchlorate plant workers subjected to the highest exposure has been estimated as approximately 0.5 mg/(kg d), as in the above paragraph, a 67% reduction of iodine uptake would be expected. effect of perchlorate upon the accumulation and reten-tion of iodide by the human thyroid gland. The effect of 1000 ppm potassium perchlorate (KClO4), 1000 ppm potassium iodide (KI) or 1000 ppm propylthiouracil (PTU) in the diet on the development of thyroid tumors was studied histologically and biochemically in Wistar rats given a single ip injection of 280 mg of N-bis(2-hydroxypropyl)nitrosamine (DHPN) per 100 g body Plusieurs cas de mortalité ont été rapportés chez des patients traités avec des perchlorates. Such an observation had immediate therapeutic application. Aucun effet sur la fonction thyroïdienne ou sur le compte des cellules sanguines n'a été observé chez ceux-ci. daily 10 mg of Perchlorate ions were ingested, an average 38% reduction in the uptake of Iodine was observed. Le perchlorate de potassium est utilisé pour traiter l'hyperthyroïdie. Celle-ci était due à une anémie aplasique causée par l'ingestion de perchlorate. Coupure temporaire des services en ligne The iodide is oxidized to neutral iodine by thyroid peroxidase at the follicular cell–colloid interface and then binds to tyrosine residues on thyroglobulin. InhalationEn cas d’inhalation, amener la personne dans un endroit aéré. Thyroid Function by Perchlorate-Contaminated Water and Food Giuseppe Lisco 1, Anna De Tullio 2, Vito Angelo Giagulli 2,3, Giovanni De Pergola 4 and Vincenzo Triggiani 2,* 1 ASL Brindisi, Unit of Endocrinology, Metabolism & Clinical Nutrition, Hospital “A. [10] "Ksp solubility product constants of many popular salts at SolubilityOFthings", "Health Effects Assessment for Environmental Perchlorate Contamination: The Dose Response for Inhibition of Thyroidal Radioiodine Uptake in Humans", "Nuclear Chemistry: Half-Lives and Radioactive Dating - For Dummies", https://en.wikipedia.org/w/index.php?title=Potassium_perchlorate&oldid=931364922, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from June 2017, Creative Commons Attribution-ShareAlike License, This page was last edited on 18 December 2019, at 13:44. Intermittent, high exposure to perchlorate for many years in male workers at an ammonium perchlorate … Potassium perchlorate is to block thyroidal reuptake (potassium perchlorate) is to block thyroidal reuptake of I- in patients with iodide-induced hyperthyroidism (amiodarone*-induced hyperthyroidism). Des coupures momentanées d’environ 5 minutes pourraient impacter les services en lig​​ne de la CNESST dimanche le 6 décembre entre 9 h et 11 h en raison d’un entretien technique. La cote entre [ ] provient de la banque Information SST du Centre de documentation de la CNESST. Perchlorate is an environmental contaminant that blocks iodine/iodide uptake into the thyroid gland (1). It is used rarely today to determine the ability to trap and organify iodine. Il peut irriter la peau. Professionnels de la santé et autres fournisseurs, Impacts du Système général harmonisé (SGH) sur le SIMDUT 1988, Guide technique d’interprétation de la législation fédérale, Modifications au Règlement sur les produits dangereux, La fiche de données de sécurité du fournisseur (FDS), La fiche de données de sécurité du lieu de travail (FDS), Guide d'utilisation d'une fiche de données de sécurité, La classification des substances et des mélanges. Although rarely utilized today in the United States for treatment of a particular type of hyperthyroidism, thyroidologists are aware that perchlorate can inhibit iodine uptake by the thyroid gland, thereby reducing its production of hormone. (less common) *Amiodarone is an iodine-containing antiarrhythmic drug. Perchlorate discharge test is used in individuals with inborn errors of thyroid hormone synthesis. Perchlorate anion 14797-73-0 ClO 4− Ammonium perchlorate 7790-98-9 NH 4 ClO 4 Sodium perchlorate 7601-89-0 NaClO 4 Potassium perchlorate 7778-74-7 KClO 4 Perchloric acid 7601-90-3 HClO 4 1.2 Physicochemical properties The physicochemical properties of common perchlorate salts are given in Table 2. with other anti-thyroid drugs) to treat amiodarone-induced thyrotoxicosis, a condition in which thyroid abnormality results from excess iodine when the iodine-containing drug amiodarone is given to control cardiac arrhythmia. It impedes the accumulation of iodide in the thyroid, which blocks thyroid hormone production. Les contenants peuvent exploser lors d'un incendie. Si l’irritation persiste, consulter un médecin. There was no significant change in thyroidal radiolabeled iodine uptake or thyroid hormone levels for either doses of perchlorate. Diagnosis of thyroid hormone production has used potassium perchlorate in some clinical settings. Fourth, thyroid peroxidase antibodies were not measured. d)), perchlorate begins to temporarily inhibit the thyroid gland's ability to absorb iodine from the bloodstream ("iodide uptake inhibition", thus perchlorate is a known goitrogen). [16] this may well be attributable to sufficient daily exposure or intake of healthy Iodine-127 among the workers and the short 8 hr Biological half life of Perchlorate in the body.[10]. Le perchlorate de potassium est utilisé pour traiter l'hyperthyroïdie. Toxicity is determined only by the perchlorate moiety of the salt. (1998) ont étudié l'effet de l'exposition au perchlorate d'ammonium, par inhalation, chez des travailleurs. Des symptômes gastro-intestinaux (nausées et vomissements) ont aussi été rapportés par des patients traités avec des perchlorates. Effects of methylmercaptoimidazole (MMI), propylthiouracil (PTU), potassium perchlorate (KClO4) and potassium iodide (KI) on the serum concentrations of thyrotrophin (TSH) and thyroid hormones in the rat Acta Endocrinol (Copenh). perchlorate de potassium Des noms Autres noms chlorate de potassium (VII); l'acide perchlorique, sel de potassium; peroidin. Pour une évaluation complète des propriétés toxicologiques, veuillez vous référer aux autres sections de cette fiche. Table 2. Perchlorate ion concentrations in a regions water supply, would need to be much higher, at least 7.15 mg/kg of body weight per day or a water concentration of 250 ppm, assuming people drink 2 liters of water per day, to be truly beneficial to the population at preventing bioaccumulation when exposed to a radioiodine environment,[10][14] independent of the availability of Iodate or Iodide drugs. Treatment of thyrotoxicosis (including Graves' disease) with 600-2,000 mg potassium perchlorate (430-1,400 mg perchlorate) daily for periods of several months or longer was once common practice, particularly in Europe, and perchlorate use at lower doses to treat thryoid problems continues to this day. Commentaires : En raison du manque de données, les classifications concernant l'irritation oculaire (H319) et  la toxicité pour certains organes cibles - exposition répétée (H372) ont été établies par analogie au perchlorate de sodium. [10][14], Prophylaxis with perchlorate containing water at concentrations of 17 ppm, which corresponds to 0.5 mg/(kg d) personal intake, if one is 70 kg and consumes 2 litres of water per day, was found to reduce baseline radioiodine uptake by 67%[10] This is equivalent to ingesting a total of just 35 mg of Perchlorate ions per day. The effects of perchlorate and thiocyanate exposure on thyroid function during the second and third trimesters of pregnancy should be studied as well. Ammonium perchlorate inhibited forelimb emergence, the percentage of animals completing tail resorption, and hindlimb development during the 70‐d exposure period. Provoque une sévère irritation des yeux (H319) Perchlorate (sometimes referred to as Perchlorate 7) is a hidden danger that has been rising to the surface over the last decade. Perchlorate can block the thyroid gland from taking up iodine, which it needs to make thyroid hormone. Celle-ci était due à une anémie aplasique causée par l'ingestion de perchlorate. (1997). Studies of chronically exposed workers though have thus far failed to detect any abnormalities of thyroid function, including the uptake of iodine. Contact avec la peauRincer immédiatement et abondamment les vêtements contaminés et la peau avec de l’eau, puis enlever les vêtements. 1 Thyroid hyperplasia, an enlargement of the gland, can be seen in this setting and is an adaptive response by the thyroid to overcome the iodine uptake block. [17], Potassium chlorate(VII); Perchloric acid, potassium salt; peroidin, InChI=1S/ClHO4.K/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1, InChI=1/ClHO4.K/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1, Except where otherwise noted, data are given for materials in their, Helmut Vogt, Jan Balej, John E. Bennett, Peter Wintzer, Saeed Akbar Sheikh, Patrizio Gallone "Chlorine Oxides and Chlorine Oxygen Acids" in. ), Oxford:Butterworth-Heinemann. Like other perchlorates, this salt is a strong oxidizer and potentially reacts with many organic substances. [10][11], Current regimens for treatment of thyrotoxicosis (including Graves' disease), when a patient is exposed to additional sources of Iodine, commonly include 500 mg potassium perchlorate twice per day for 18–40 days. Potassium perchlorate given orally resulted in a rapid release of accumulated intrathyroidal iodide in GD patients treated with thionamide . Potassium perchlorate is prepared industrially by treating an aqueous solution of sodium perchlorate with potassium chloride. Pour en savoir plus sur le projet de loi modernisant le régime de santé et de sécurité du travail et suivre l’évolution des travaux parlementaires, consultez le site de l’Assemblée nationale.​​​​​​​​​, CNESSTSanté et sécurité du travailPréventionRépertoire toxicologiqueFiche complète. Treatment of thyrotoxicosis (including Graves disease) with 600–2000mg potassium perchlorate (430–1400mg perchlorate) daily for periods of several months or Trapping, or uptake, can be blocked competitively by monovalent anions (e.g., potassium perchlorate). Istituto Oncologico Veneto; Research output: Contribution to journal › Article › peer-review. Treatment regimens include potassium perchlorate at 500 mg twice per day for 18-40 days (Bartalena et al., 1966) and